Usually within the first year of life, growth of a child with progeria slows markedly so that height and weight fall below average for his or her age, and weight falls low for height. A child with progeria develops an appearance typical of those with the disorder, including a narrowed face and beaked nose, which makes the child look old.

Motor development and mental development remain normal. Other signs and symptoms of this progressive disorder include:

  • Hair loss (alopecia), including eyelashes and eyebrows
  • Hardening and tightening of skin on trunk and extremities (scleroderma)
  • Loose, aged-looking skin
  • Head too large for face
  • Prominent scalp veins
  • Prominent eyes
  • Small lower jaw (micrognathia)
  • High-pitched voice
  • Delayed and abnormal tooth formation
  • Loss of body fat and muscle
  • Stiff joints
  • Hip dislocation

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